Businesses for Sale in Des Moines, Iowa

Health Care & Fitness

This established non-surgical regenerative medical practice represents a compelling acquisition opportunity in the growing alternative healthcare sector. Located in West Des Moines, the practice specializes in cash-pay treatment protocols for patients experiencing joint pain, arthritis-related conditions, and mobility challenges. Financial Performance: The practice demonstrates consistent profitability with annual revenues exceeding $1.2 million and EBITDA averaging $303,000 over the past three years, including $322,000+ in the most recent period. These results are achieved while operating only six days per month, indicating significant operational efficiency and growth potential. Operational Infrastructure: The business benefits from comprehensive operational support including trained clinical staff, established treatment protocols, and franchise backing. The practice utilizes Salesforce-based patient tracking systems and maintains standardized procedures that facilitate seamless operations and potential expansion. Growth Opportunities: The limited operating schedule presents immediate expansion possibilities through increased availability and enhanced local market penetration. The existing marketing framework and established patient acquisition systems provide a foundation for scaling operations. Transaction Details: The opportunity is SBA-eligible for qualified purchasers. Medical licensure is not required for ownership, broadening the potential buyer pool. The seller will provide comprehensive transition assistance to ensure continuity of operations. Support Systems: Included assets encompass trained personnel, established clinical protocols, franchise support infrastructure, and comprehensive patient management systems. The practice operates within the cash-pay model, eliminating insurance reimbursement complexities. This acquisition opportunity offers an established revenue stream in the expanding regenerative medicine market with demonstrated profitability and significant potential for operational enhancement under new ownership.

Health Care & Fitness

This is a franchise listing. This upscale wellness and aesthetics clinic delivers a full suite of anti-aging, detox, and body-enhancement treatments, combining clinical expertise with a spa-like experience. The sale includes all furniture, equipment, and inventory—making it a true turnkey opportunity. The core focus is on lymphatic and digestive detoxification along with advanced body sculpting services. Using proprietary, results-oriented methods, the clinic helps clients improve their health from the inside out. As a brand solely focused on lymphatic wellness, it has carved out a unique niche and built a strong, loyal customer base—97% of whom are women. Clients report noticeable results such as decreased bloating and water retention, improved digestion, toxin release, and visible body contouring improvements—all within a relaxing, high-end environment designed to promote restoration and well-being. The business operates on a cash-pay model with a high average transaction size and consistent recurring revenue driven by memberships. It can be managed semi-absentee, and comprehensive training and ongoing corporate support are provided. No medical or aesthetic background is necessary—strong leadership and an interest in health and wellness are what matter most. Opportunities for multi-unit growth are also available in the area.

Health Care & Fitness

This chiropractic clinic boasts gross collections of $225,000 and has been in operation for 18 years. With a focus on family practice and sports medicine, it offers a turnkey solution with abundant new patients and proven marketing strategies. The clinic features a well-optimized website and a stellar reputation, ensuring a smooth transition for new ownership. Located in a thriving neighborhood, the 1,950 sq. ft. facility includes valuable equipment such as an on-site digital X-ray. Opportunities for growth and a balanced work-life schedule are supported by established systems.

Service Businesses

This established Des Moines Metro floor care business offers an opportunity to acquire a recognized local company with a loyal customer base, experienced team, and strong reputation for quality service. The company provides professional cleaning services across a variety of flooring and surface types, allowing it to serve a broad range of residential and commercial customer needs. An experienced team handles day-to-day service delivery, providing operational continuity. With an established customer base, proven service capabilities, and multiple avenues for future growth, the business provides a solid foundation for a new owner to build upon.

Other

A profitable ATM business with 30 well-maintained machines strategically located throughout the Des Moines metropolitan area, serving locations where quick access to cash is essential. The business includes a longstanding relationship with a local bank for funds transfer processing, allowing a seamless transition for a new owner to start generating revenue.

Financial Services

This is an established independent insurance agency with a diversified book across commercial and personal lines. Revenue is largely recurring, supported by long-term client relationships and strong carrier partnerships. The agency operates with efficient systems and a lean structure, producing consistent cash flow. The business serves clients across multiple states, which reduces concentration risk and supports scalability. Its independent model allows flexibility in carrier placement, pricing, and coverage solutions, creating durable client retention and cross-sell opportunities. Growth opportunities include cross-selling to existing clients, deeper personal lines, expanding life and supplemental products, and targeted marketing within existing territories. The platform is well suited for an owner-operator seeking steady income or a strategic buyer looking to add scale, geographic reach, and predictable commissions.

Restaurants & Food

This neighborhood pub combines a welcoming atmosphere with quality food and a full-service bar. Known for live events and a casual dining experience, it is a staple within the local community. The business offers a great opportunity for a new owner to capitalize on its established reputation and expand its offerings.