Businesses for Sale in Buffalo, New York

Restaurants & Food

Turnkey upscale restaurant in desirable Buffalo neighborhood. Loyal clientele. Google rating of 4.7. Reasonable rent. Owner is absentee and key staff will stay for right proposal. Currently only open Thursday-Saturday. Potential for more hours/brunch. Many other restaurants in area and movie theater next door, providing steady traffic.

Other

Position your business for immediate growth with this turnkey, licensed, and operating cannabis processing and distribution facility located in Western New York. This fully operational asset sale includes both a Tier 1 Processing License and Distribution License, offering investors, operators, and established brands an opportunity to acquire a compliant, ready-to-operate platform in one of New York’s emerging cannabis markets. This license pairing allows operators to perform any type of processing and all forms of manufacturing, as well as distribute products directly to all license types. Offered for $1,100,000, the facility consists of approximately 4,536 square feet of Class B commercial warehouse space featuring 18-foot ceilings, 300-amp electrical service, a roll-up door, and a man door. The lease is $6,950 per month with a one-year minimum term and two options to extend, providing long-term operational flexibility. Included in the transaction is more than $650,000 in processing and manufacturing equipment, transferable operating infrastructure, and a valuable customer relationship management (CRM) database containing contact information and warm introductions to over 100 licensed retailers that currently carry or have previously carried the company’s products. Whether you’re an experienced cannabis operator looking to expand your footprint or looking to immediately start a new business in New York, this opportunity offers an attractive combination of valuable assets and turn-key access to one of the largest and fastest growing markets in the US. Serious inquiries only. Additional information will be provided upon execution of a confidentiality agreement (NDA). Details: Space: 4.5k SqFt Rent: $6,950/Month Lease Term: 1YR w/ 2 Options to Extend Business Type: Licensed Cannabis Processing & Distribution Facility Estate: Leased Warehouse – Class B Commercial Ceiling Height: 18’ Power: 300 AMP Loading Access: Roll-up door and man door CRM: Contact information and introductions to all ~100 retailers that are currently (or have) carried products Equipment Value: $650K+ Licenses: Tier 1 Cannabis Processing License – authorizes the holder to manufacture, process, package, and label cannabis products for distribution to licensed retailers and distributors within the state. This license type permits a wide range of activities, including extraction, infusion, and the production of products such as edibles, tinctures, concentrates, and topicals, provided all operations comply with New York State Office of Cannabis Management (OCM) regulations. Cannabis Distribution License – authorizes the holder to purchase cannabis products from licensed cultivators and processors and distribute them to licensed dispensaries and retail operators within the state. Distributors serve as the critical logistics link in the supply chain, ensuring that products move compliantly from production to retail. Asking Price: $1,100,000 or option for discounted pricing without equipment Must sign an NDA/Waiver before any other detailed information is released, along with the company’s location. This listing is Fully Exclusive only by Green Life Business Group, Inc. Green Life Business Group, Inc DRE CA LIC# 02061374 Eric Espinoza, DRE LIC CA #02077927 If you have any questions Call Eric (858) 245-6324 Email: broker@glbgroupinc.com National Affiliate Listings All listings included in this section are represented by locally licensed real estate brokers where necessary. Green Life Business Group Inc. we are here to both help you sell or buy a cannabis business opportunity. Disclaimer: The content of this listing is based solely on information provided by the seller to Green Life Business Group, Inc. Green Life Business Group, Inc has not independently verified or confirmed the accuracy, completeness, or reliability of any such information and makes no representation or warranty, express or implied, regarding it. Any party relying on the description or other listing information should conduct its own independent due diligence and verification.

Health Care & Fitness

This is a franchise listing. This upscale wellness and aesthetics clinic delivers a full suite of anti-aging, detox, and body-enhancement treatments, combining clinical expertise with a spa-like experience. The sale includes all furniture, equipment, and inventory—making it a true turnkey opportunity. The core focus is on lymphatic and digestive detoxification along with advanced body sculpting services. Using proprietary, results-oriented methods, the clinic helps clients improve their health from the inside out. As a brand solely focused on lymphatic wellness, it has carved out a unique niche and built a strong, loyal customer base—97% of whom are women. Clients report noticeable results such as decreased bloating and water retention, improved digestion, toxin release, and visible body contouring improvements—all within a relaxing, high-end environment designed to promote restoration and well-being. The business operates on a cash-pay model with a high average transaction size and consistent recurring revenue driven by memberships. It can be managed semi-absentee, and comprehensive training and ongoing corporate support are provided. No medical or aesthetic background is necessary—strong leadership and an interest in health and wellness are what matter most. Opportunities for multi-unit growth are also available in the area.

Pet Services

This veterinary practice, staffed by one DVM, is situated in the serene suburbs northeast of Buffalo. It provides an ideal work-life balance with no night or weekend shifts, allowing for personal time outside of work. The clinic is conveniently located near a prominent university and benefits from a highly rated local school system. After covering debt service, the practice generates an income exceeding $200,000. Explore this clinic through a virtual tour.

Online & Technology

Transworld Business Advisors presents a 28-year-old, founder-owned online retailer generating approximately $13 million in annual net sales and $1.44 million in FY2025 SDE — designing, manufacturing, and fulfilling a catalog of roughly 17,000 SKUs from a single purpose-built facility in Western New York. Owner works part time, 10 hr/week. Experienced management is in place and wants to stay. Over 30 employees. Business has SBA pre-qualification. Building is for sale or lease back from the seller. Inventory included (>$2M) The company is among the largest independent specialists in its category, and one of a handful of internet-native retailers of any kind to have thrived across three decades of fashion cycles and platform shifts. Revenue flows through a branded Shopify storefront (≈85% of sales), a native mobile app with materially higher order values, Amazon US (growing ≈25% in 2026), Walmart, Etsy, and TikTok Shop. Behind those channels sits a fully owned audience of 2.6MM email profiles, 1.2MM SMS subscribers, and 3.9MM+ social followers — a marketing asset the buyer owns from day one rather than having to build. An in-house gold department, led by a master jeweler and certified gemologist, produces 14k and 18k gold, diamond, and lab-grown-diamond pieces in the USA — a position no marketplace seller or drop shipper can replicate at the company's price point. Investment Highlights: Inventory Included in the Price (>$2M) Real Estate available for purchase or lease back from seller Durable, diversified revenue: ≈$13MM for three straight years across six sales channels; ≈360K orders per year with zero customer concentration. Vertical integration: in-house manufacturing, laser customization, photography studio, and fulfillment under one roof. Owned audience at scale: email returns ≈4× and drives ≈12% of DTC revenue; 40% of customers are repeat buyers contributing ≈46% of sales. Management in place: VP of Operations with 23 years' tenure and department leads of 10–20+ years; the owner works ≈10 hours/week remotely. Growth levers unpulled: Amazon, mobile app, TikTok Shop, subscriptions, wholesale re-entry, international reactivation. Bonus second brand: a complete, USA-made consumer brand with its own equipment and 1.4MMprofile email list conveys at no additional cost. Qualified buyers need to take a look at this one.

Manufacturing

Join the outdoor recreation industry with a unique set of patented products designed for DIY builders in the backyard rink category. This opportunity offers high profit potential, competitive pricing, and a quick return on investment, with a focus on strategic marketing efforts to drive growth. Explore the exciting world of iceboxrinks.com for more details.

Restaurants & Food

This Japanese and Chinese flavors restaurant is up for grabs at an attractive price of $50,000, including $40,000 worth of furniture, fixtures, and equipment. Situated off a busy thoroughfare with excellent accessibility, this 2,043 sq. ft. facility is ideal for any restaurant concept, café, takeout, or specialty food operation, offering a rare opportunity to own a fully equipped location for a fraction of the cost of building one from scratch.