Businesses for Sale in Syracuse, New York

Transportation & Storage

Introducing an incredible opportunity in Syracuse, NY! EMPIRE DM offers a thriving 30+ VEHICLE MEDICAL TRANSPORTATION BUSINESS for sale. Boasting over 60 vehicles, 30 of them DOT compliant vehicles, most ADA-certified, this turnkey operation has been successfully running for over 30 years. With established contracts in place with prominent CNY government, education, and healthcare institutions, the business is currently operating absentee/remote and generating annual billings ranging from $3-6M, with new lucrative contracts secured for 2026. This opportunity includes 8,000 square feet of space featuring professional offices, training facilities, repair, and warehouse areas. The current owner is willing to assist with transition/training, and there are 30 dedicated staff members ready to continue with the business. Don't miss out on this chance to own a well-established and lucrative medical transportation business with substantial growth potential!

Health Care & Fitness

This is a franchise listing. This upscale wellness and aesthetics clinic delivers a full suite of anti-aging, detox, and body-enhancement treatments, combining clinical expertise with a spa-like experience. The sale includes all furniture, equipment, and inventory—making it a true turnkey opportunity. The core focus is on lymphatic and digestive detoxification along with advanced body sculpting services. Using proprietary, results-oriented methods, the clinic helps clients improve their health from the inside out. As a brand solely focused on lymphatic wellness, it has carved out a unique niche and built a strong, loyal customer base—97% of whom are women. Clients report noticeable results such as decreased bloating and water retention, improved digestion, toxin release, and visible body contouring improvements—all within a relaxing, high-end environment designed to promote restoration and well-being. The business operates on a cash-pay model with a high average transaction size and consistent recurring revenue driven by memberships. It can be managed semi-absentee, and comprehensive training and ongoing corporate support are provided. No medical or aesthetic background is necessary—strong leadership and an interest in health and wellness are what matter most. Opportunities for multi-unit growth are also available in the area.

Health Care & Fitness

This is a unique chance to take over a well-established optometry practice located in North Syracuse, New York, operating since 1996. The current owner is retiring after a successful 35-year career, providing a qualified buyer with a fully equipped and turnkey practice that includes loyal patients and trained staff. The practice offers a range of services including comprehensive vision exams, ocular disease management, and a retail optical dispensary, with appointments consistently booked 4 to 6 weeks in advance. Financially, the practice has shown stable revenues supported by a diverse payer mix and is priced at $550,000, which includes approximately $185,000 in equipment. The practice operates from a 2,244 sq. ft. commercial building at 105 N Main Street, featuring 15 parking spaces and a professionally designed interior. The building can be purchased separately for $400,000 or together with the practice for $950,000. The location is poised for growth due to the nearby Micron Technology semiconductor campus, expected to create thousands of jobs and increase demand for healthcare services. The practice operates 4 days a week and offers significant opportunities for growth through extended hours or additional services. The sale includes all necessary equipment, inventory, and transition support from the retiring owner, with confidentiality maintained throughout the inquiry process.

Service Businesses

Established Commercial Cleaning & Facility Services Company | 38+ Years of Proven Success Acquire a highly respected, family-owned commercial cleaning and facility services company with a 38+ year history of delivering dependable, high-quality service throughout its market. The company has built a loyal and diversified customer base through exceptional customer service, consistent performance, and long-standing client relationships.Services include commercial and office cleaning, janitorial services, carpet cleaning, floor maintenance and restoration, window cleaning, and other facility care solutions. The business is supported by an experienced operations team, allowing for a smooth ownership transition and limited day-to-day owner involvement.The company's reputation for quality, professionalism, and responsiveness has generated strong customer retention and recurring revenue, creating a stable foundation for future growth. Significant opportunities exist to expand geographically, increase service penetration with existing clients, and pursue additional commercial contracts. Investment Highlights Established and trusted brand with 38+ years of operating history Strong recurring revenue from long-term commercial clients Excellent reputation for quality workmanship and customer service Experienced management and operations team in place Diverse service offerings with broad customer appeal Proven history of repeat business and customer retention Consistent cash flow and predictable revenue streams Scalable platform with opportunities for growth and expansion Family-owned business with a well-defined operating model Essential service industry with resilient demand This is a rare opportunity to acquire a market-leading commercial cleaning company with decades of operating success, a loyal customer base, and a strong foundation for continued growth. Ideal Buyer: Strategic cleaning or facility services company seeking expansion, private investor/operator, or entrepreneur looking for an established business with recurring revenue and experienced staff in place.

Real Estate

Listed at $550,000, this property on 517 S Main St is situated in a high-traffic zone, easily accessible and primed for renovation, located just a short distance from Syracuse’s vibrant hotspots.

Real Estate

Available for $689,000, this property features 9 apartments and 2 storefronts in a bustling area. It's conveniently located just minutes from Downtown Syracuse and other key attractions.

Franchise Resales

This well-known dessert franchise operates in the Syracuse, NY area, boasting around $1.15 million in revenue over the past year and approximately $210,000 in Seller’s Discretionary Earnings. The establishment is fully outfitted and run by a skilled team, allowing the owners to take a step back from daily operations, focusing mainly on administrative tasks like bookkeeping and community engagement. Strong ties have been built with local schools and organizations through various programs, with room for further growth in partnerships with colleges and businesses. Situated in a developing region of Onondaga County, the business benefits from ongoing economic improvements. The current owners are nearing retirement and will assist in the transition for a suitable buyer. Note that this franchise is not approved for SBA financing, so buyers should consider conventional financing options or cash. Seller financing may be available depending on the transaction terms, and buyer approval by the franchisor is required. Confidentiality agreements and buyer qualifications will be necessary to access brand and financial details.

Retail

This convenience store boasts an established customer base, exceptional sales, and a strong social media following for effective online marketing campaigns. Situated in a high foot traffic area, it has a successful track record.

Building & Construction

This profitable office furniture installation company is a trusted partner for businesses upgrading, expanding, or relocating their workspaces. With a skilled crew, efficient processes, and a reputation for reliability, the company delivers seamless installations for cubicles, workstations, conference rooms, and specialty commercial environments. The business enjoys steady demand from office furniture dealers, contractors, and corporate clients. Strong margins, repeat business, and opportunities for expansion into design, project management, or warehousing make this a compelling opportunity for a motivated buyer. Current pipeline of work indicates 2026 is show growth! Call or email Kevin Everts: 315-962-9200 or keverts@tworld.com

Building & Construction

This highly profitable general contracting construction business offers the following services: 1. Design/Build General Contracting 2. Home Improvements and Home Additions 3. Commercial Construction Projects This business, which is recognized for its expertise in all phases of a construction project, is highly respected in its industry and is well known for the excellent customer service it provides. Because the company has a solid reputation as a reliable business partner it is a preferred contractor on the "Bid List" of several well established architects. The buyer of this business will inherit valuable Work-In-Progress and Work-Backlog assets. That said, as of January 1, 2026 the company has approximately $600,000 of Work-Backlog jobs to be started. The business comes with a well trained and experienced staff. Most importantly, this business brings to the table a proven track record of success. Its year to year cash flow is strong, and the owner enjoys a good, consistent profit margin. In short, the seller's objective is to turn over the operation of the business to another general contracting firm, or to an individual with experience in the construction industry and a drive to continue growing the company.

Automotive & Boat

Sales and service of Commercial & Passenger tires, servicing all of Onondaga County. 9,500 sq ft leased facility, with a large long-term passenger and commercial customer base, many of which are well known names in Greater Syracuse. 2025 was another solid year for ownership.