Businesses for Sale in Columbia, South Carolina

Health Care & Fitness

This is a franchise listing. This upscale wellness and aesthetics clinic delivers a full suite of anti-aging, detox, and body-enhancement treatments, combining clinical expertise with a spa-like experience. The sale includes all furniture, equipment, and inventory—making it a true turnkey opportunity. The core focus is on lymphatic and digestive detoxification along with advanced body sculpting services. Using proprietary, results-oriented methods, the clinic helps clients improve their health from the inside out. As a brand solely focused on lymphatic wellness, it has carved out a unique niche and built a strong, loyal customer base—97% of whom are women. Clients report noticeable results such as decreased bloating and water retention, improved digestion, toxin release, and visible body contouring improvements—all within a relaxing, high-end environment designed to promote restoration and well-being. The business operates on a cash-pay model with a high average transaction size and consistent recurring revenue driven by memberships. It can be managed semi-absentee, and comprehensive training and ongoing corporate support are provided. No medical or aesthetic background is necessary—strong leadership and an interest in health and wellness are what matter most. Opportunities for multi-unit growth are also available in the area.

Service Businesses

Launched in 2021, this waste services franchise has established a solid operational base catering to the Columbia area and nearby markets in South Carolina. It provides a diverse fleet of roll-off dumpsters and portable toilets in various sizes. Over its four years of operation, the business has cultivated a loyal customer base, strong industry connections, and a reputation for reliable service. With a TTM revenue of $951,560 and an SDE of around $164,422, the company has shown impressive year-over-year growth. Currently, the ownership is semi-absentee, with a General Manager handling daily operations, making it a turnkey opportunity for new owners. The asking price covers all trucks, dumpsters, and portable toilets, including 3 roll-off trucks, 68 dumpsters, and 49 portable toilets, all free of liens at closing. The tangible asset base is valued at approximately $580,500. Qualifying assets might qualify for Section 179 expensing, and buyers are advised to consult their tax professionals. The business has exclusive franchise rights throughout South Carolina, with many territories still available for development, offering significant growth potential for an ambitious buyer. It also holds commercial contracts and ongoing dumpster placements, ensuring a steady stream of predictable revenue.

Building & Construction

This residential garage door service business offers a rare opportunity to acquire an established home services company in the growing Midlands region of South Carolina. Backed by a nationally recognized franchise brand, the company provides garage door repair, replacement, installation, opener services, emergency repairs, and preventative maintenance to a large and expanding customer base. One of the business's most valuable assets is its exceptional reputation in the marketplace, reflected by over 800 five-star Google reviews. This level of customer validation is difficult to replicate and provides a new owner with immediate trust, strong lead generation potential, and a dominant online presence. Supported by recurring service demand, diverse revenue sources, and a substantial installed customer base, the business offers a proven platform for continued growth. For buyers looking to enter the home services sector, this is an opportunity to step into an established operation with brand recognition, strong community credibility, and a history of delivering outstanding customer service.

Health Care & Fitness

This thriving solo-doctor small animal veterinary practice has been serving the community for 57 years, generating an impressive annual revenue of $1,175,000 and over $215,000 in income after debt. Operating Monday to Friday from 8:00 AM to 4:00 PM, the facility features two exam rooms and advanced diagnostic tools such as Digital Radiography, CO2 Laser, and IDEXX equipment. Situated in a standalone 2,535 sq. ft. building, the real estate is also available for purchase. Located in Richland County, it offers a compelling mix of affordability, growth potential, and quality living. The practice has a solid history since 1969, affirming the area's stability and viability. The St. Andrews community, with around 20,675 residents, is part of the Columbia metropolitan area, which boasts a population exceeding 144,000, providing a substantial client base. The location enjoys easy access to major highways, with traffic counts surpassing 22,500 vehicles daily, ensuring excellent visibility. Nearby amenities include Lake Murray, the Saluda River corridor, and various dining and shopping options. The Columbia area is supported by a diverse employment landscape, including major employers like Prisma Health and the University of South Carolina, along with corporate giants such as Wells Fargo and Amazon, making it an attractive site for veterinary practice ownership and growth.

Service Businesses

Offering non-toxic carpet, upholstery, rug, and tile cleaning in Columbia and nearby areas. This turnkey business includes a sales representative, franchise expansion potential, and ongoing support. Services include safe upholstery cleaning, specialty stain removal, and more.

Health Care & Fitness

Experience a nearly 100% referral-based chiropractic practice in NW Columbia, benefiting from a supportive environment near a growing lake community. The owner offers vacation coverage for a smooth transition, ensuring work–life balance for the new owner, with easy access to outdoor recreation and proximity to the mountains and coast.

Retail

Refurbished! Renovated! Modernized! The perfect neighborhood bar in a high-traffic area of the fastest-growing part of Columbia, South Carolina is up for sale. This amazing little bar has undergone a transformation over the past year and is now backed by results. The current owners, who are relocating out of the area, have provided a face-lift on the entire building and the growth has been incredible. By adding live entertainment, the business has become a popular destination for the local clientele. All inventory and FF&E is included in the sale price. There is no better definition of a turnkey business than this. Begin earning on your investment from the moment you unlock the door on day one.

Retail

This remarkable little bar has undergone a transformation over the past year and is truly successful. Located in a busy and fast-growing part of the South Carolina Midlands, it is priced to sell and can provide a new owner with an impressive return from day one. The current owners have upgraded the entire facility and expanded the offerings to include more food and live entertainment. A loyal clientele keeps this neighborhood bar humming for 18 or so hours every day. A great staff is in place, and the owners, who will be relocating, are willing to coach up and train a new owner for a couple of weeks. All inventory and FF&E are included in the sales price. Get a business that cash flows just under $100K and enjoy the profits immediately.

Retail

2 incredibly profitable bars located next to each other for the price of 1! Take a look at these two businesses priced to move. Extremely easy to operate. This is a golden opportunity to reach two distinct clienteles in more-or-less one location. Both bars conveniently located along a busy stretch of residential and commercial. After spending a year upgrading both bars, the owners are relocating. Their expanded marketing efforts, along with a focus on live entertainment and other in-person special events, have grown these establishments into neighborhood gathering spots for a large number of local—and loyal—customers. The profits will be flowing for you from the day you first open the doors. Here's a chance to own a business where everyone knows everyone else's name. Coin-operated pool tables and juke boxes, along with the beer and liquor, provide terrific margins in a business that is not trendy, but steady.

Restaurants & Food

Step into ownership of a turnkey box lunch delivery and catering franchise in Columbia, SC, with $300K in equipment included. This established business comes with trained staff, a loyal customer base, and growth potential in expanding into nearby areas like Sumter and Fairfield County. Ideal for a hands-on owner/operator looking to take over a recognized franchise brand with stable sales and profits.

Service Businesses

Discover a professional cleaning service specializing in non-toxic, green-certified carpet, upholstery, rug, and tile cleaning in Columbia, South Carolina. Utilizing a unique hot carbonating extraction process, this turnkey business opportunity offers immediate growth potential with existing relationships, contacts, and contracts in place. Services include carpet cleaning with a proprietary eco-friendly solution, upholstery cleaning, specialty stain removal, and more. The business operates from the owner's home, making it a convenient and scalable option for expansion. Ideal for a buyer seeking a well-established service business.